GeneSavvy Maximized Wellness Report

This PDF-style report was built for those functional health practitioners, fierce warrior moms, and advanced biohacking geeks that want to explore their genetic data related to specific functional health topics related to maximized wellness!

Our Maximized Wellness Report includes:

  • Functional health networks prioritized for maximized wellness, based on your genetics:
    • Detoxification: Phase 1
    • Detoxification: Phase 2
    • Inflammation
    • Iron
    • Lipid Metabolism
    • Methylation
    • Musculoskeletal Stability
    • Oxidative Stress
    • SARS CoV-2 Severity
  • Unique and potentially significant variants that may impact the function of the genes covered in this report
  • Researched SNPs and variants related to the functional health networks in this report
  • Actionable functional health network guides that contain:
    • Action Items for Maximized Wellness
    • Clinical Exploration and Diagnostic Tools
    • Nutritional Support and Treatment Considerations
    • Overview of Genes, their variants, and their role within the related functional health network
  • Gene reference library that contains:
    • More detailed information about each gene covered by this report
    • All variants found within the coding regions (exons) of the genes covered by this report
    • Links and resources for continued research of the unique genes and variants contained in your report
  • And more***

***We are continuously pioneering new analysis tools to help identify functional genetic patterns between disease associated rare variants, lifestyle changing polymorphisms, real-time protein/enzyme activity, and environmental factors which we use to provide actionable options for vibrant life longevity. Many of these tools can be used to enhance and add information to your GeneSavvy reports without the need for collecting new saliva samples and re-testing.

Functional data enrichment

Data enrichment is all about creating more actionable insights through associations. We’ve built our own custom enrichment database that is full of clinical actionability for functional health practitioners.
We are constantly adding new information to our databases, providing new insights into gene/variant associations with health-related pathways, cellular & molecular functions, lab biomarkers, interactions with pharmaceuticals, food/nutrients, environmental factors, vitamins/herbs, and MORE. Our roots are in functional medicine, so our enrichment data is geared around terms that functional health practitioners can easily use to guide action.
*Not all genes/variants are currently enriched by our database. Our database will continue to grow as research continues.

Built for functional medicine

Our reports were built with functional medicine practitioners in mind, so the results and terminology used in our reports will be easy to understand and work with in functional clinical settings.

Personalized results

We use genetics to develop more personalized approaches to functional medicine. That’s why we prioritize the less common variants found in each gene, those are the genetic markers that make people different!

Actionable genetic associations

We work hard to include clinically-actionable associations for the results outlined in our reports. Those actionable associations can include further recommended lab testing, treatments, clinical action bullet points, and environmental interactions related to the genes and gene networks.

Battle tested

All of our genetic reporting tools began as custom-built solutions for real-life cases in which we were contracted to help practitioners get better insights into finding the missing pieces keeping their patients from making progress. The custom reports built to break ground for those patients and practitioners have been redesigned to produce the reports we offer to you today.
If you need a custom genetic tool or report built to help assist in a complex health case, please contact us at [email protected]

Treatment modalities combined

Our GeneSavvy advisors, panel curators, and action research experts have come together from many different modalities of the health industry to provide a well-rounded set of genetic data associations without bias towards one approach or another, it’s all about providing the best insights for you in all aspects of health! Some of the backgrounds of our experts include:

Medical Doctors
Functional Medicine Practitioners
Naturopathic Doctors
Doctors of Osteopathic Medicine
Genetic Counselors
Nutritionists and Other Functional Health Professionals.

With a quick upload, you can squeeze more actionable information out of the genetic data you already have!

Step 1

Make sure you have a VCF file type.

Your file(s) must be VCF files. It’s not uncommon for raw data from your lab to be divided into more than one file; make sure all of them are VCF files. If you have genetic data in the form of a TXT, BAM, or FASTQ file contact us at [email protected] or (425) 686-0000.

Step 2

Compress the file(s)

Because raw data files can be large, and because there can be more than one file per person, we require you to compress your files before uploading. Most Windows and Mac computers have a built-in file compression option on right-click. The compressed file will usually have a .zip or .gz extension. If you are submitting data for more than one person (such as in the case of submitting all members of a family) please compress the files for each person separately.

Step 3


Once you pay for the GeneSavvy Maximized Wellness Report you will be prompted to upload your file(s). Your upload request email should show up within half an hour. Please check your spam and trash folders. If you don’t receive an upload request email, please contact us at [email protected] or (425) 686-0000.

Step 4

Receive your report

Once your files have been successfully uploaded, your report should be available for you to download within 24 hours. If you don’t receive your report, please contact us at [email protected] or (425) 686-0000.

Our GeneSavvy Maximized Wellness Report includes analysis of ALL the protein-coding(exon) portions of the genes listed below and we report any variants that may disrupt gene and/or protein function. In addition to all the protein-coding variants, we report genotype information for well-researched and popular genes, variants, and SNPs, that may help your functional medicine team develop more personalized and more effective health and lifestyle recommendations.


The following GENES are analyzed in your GeneSavvy Maximized Wellness Report:

ABO ABO Blood Group (Basepairs analyzed: All Exon Locations)
APOA2 Apolipoprotein A2 (Basepairs analyzed: All Exon Locations)
APOC3 Apolipoprotein C3 (Basepairs analyzed: 3,163)
APOE Apolipoprotein E (Basepairs analyzed: 3,877)
BMP2 Bone Morphogenetic Protein 2 (Basepairs analyzed: All Exon Locations)
C4BPA Complement Component 4 Binding Protein Alpha (Basepairs analyzed: All Exon Locations)
CAT Catalase (Basepairs analyzed: All Exon Locations)
CBS Cystathionine Beta-Synthase (Basepairs analyzed: 23,171)
CETP Cholesteryl Ester Transfer Protein (Basepairs analyzed: 21,954)
CILP Cartilage Intermediate Layer Protein (Basepairs analyzed: All Exon Locations)
COL10A1 Collagen Type 10 Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COL1A1 Collagen Type I Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COL2A1 Collagen Type 2 Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COL3A1 Collagen Type 3 Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COL4A1 Collagen Type 4 Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COL5A1 Collagen Type 5 Alpha 1 Chain (Basepairs analyzed: All Exon Locations)
COMT Catechol-O-Methyltransferase (Basepairs analyzed: 28,235)
CRP C-Reactive Protein (Basepairs analyzed: All Exon Locations)
CXCR6 C-X-C Motif Chemokine Receptor 6 (Basepairs analyzed: All Exon Locations)
CYP1A1 Cytochrome P450-1A1 (Basepairs analyzed: All Exon Locations)
CYP1A2 Cytochrome P450-1A2 (Basepairs analyzed: All Exon Locations)
CYP2A6 Cytochrome P450-2A6 (Basepairs analyzed: All Exon Locations)
CYP2C19 Cytochrome P450 2C19 (Basepairs analyzed: All Exon Locations)
CYP2C9 Cytochrome P450 2C9 (Basepairs analyzed: All Exon Locations)
CYP2D6 Cytochrome P450-2D6 (Basepairs analyzed: All Exon Locations)
CYP2E1 Cytochrome P450-2E1 (Basepairs analyzed: All Exon Locations)
CYP3A4 Cytochrome P450-3A4 (Basepairs analyzed: All Exon Locations)
CYP3A5 Cytochrome P450-3A5 (Basepairs analyzed: All Exon Locations)
F3 Coagulation Factor 3, Tissue Factor (Basepairs analyzed: All Exon Locations)
GPX1 Glutathione Peroxidase 1 (Basepairs analyzed: All Exon Locations)
GSTA1 Glutathione S-Transferase Alpha 1 (Basepairs analyzed: All Exon Locations)
GSTM1 Glutathione S-Transferase Mu 1 (Basepairs analyzed: All Exon Locations)
GSTO1 Glutathione S-Transferase Omega 1 (Basepairs analyzed: All Exon Locations)
GSTP1 Glutathione S-Transferase Pi 1 (Basepairs analyzed: All Exon Locations)
HAMP Hepcidin Antimicrobial Peptide (Basepairs analyzed: All Exon Locations)
HFE Homeostatic Iron Regulator (Basepairs analyzed: All Exon Locations)
HJV Hemojuvelin (Basepairs analyzed: All Exon Locations)
ICAM1 Intercellular Adhesion Molecule 1 (Basepairs analyzed: All Exon Locations)
IL17A Interleukin 17 Alpha (Basepairs analyzed: All Exon Locations)
IL1A Interleukin 1 Alpha (Basepairs analyzed: All Exon Locations)
IL1B Interleukin 1 Beta (Basepairs analyzed: All Exon Locations)
IL1RN Interleukin 1 Receptor Antagonist (Basepairs analyzed: All Exon Locations)
IL6 Interleukin 6 (Basepairs analyzed: All Exon Locations)
LPL Lipoprotein Lipase (Basepairs analyzed: 28,188)
MTHFR Methylenetetrahydrofolate Reductase (Basepairs analyzed: 20,373)
MTR 5-Methyltetrahydrofolate-Homocysteine Methyltransferase (Basepairs analyzed: 108,700)
MTRR 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase (Basepairs analyzed: 49,938)
NAT1 N-Acetyltransferase 1 (Basepairs analyzed: All Exon Locations)
NAT2 N-Acetyltransferase 2 (Basepairs analyzed: All Exon Locations)
NFE2L2 Nuclear Factor, Erythroid 2 Like 2 (Basepairs analyzed: All Exon Locations)
NOS1 Nitric Oxide Synthase 1 (Basepairs analyzed: All Exon Locations)
NOS2 Nitric Oxide Synthase 2 (Basepairs analyzed: All Exon Locations)
NOS3 Nitric Oxide Synthase 3 (Basepairs analyzed: All Exon Locations)
NQO1 NAD(P)H Quinone Dehydrogenase 1 (Basepairs analyzed: All Exon Locations)
PON1 Paraoxonase 1 (Basepairs analyzed: 26,215)
SLC11A2 Solute Carrier Family 11 Member 2 (Basepairs analyzed: All Exon Locations)
SLC40A1 Solute Carrier Family 40 Member 1 (Basepairs analyzed: All Exon Locations)
SOD1 Superoxide Dismutase 1 (Basepairs analyzed: All Exon Locations)
SOD2 Superoxide Dismutase 2 (Basepairs analyzed: All Exon Locations)
SOD3 Superoxide Dismutase 3 (Basepairs analyzed: All Exon Locations)
TF Transferrin (Basepairs analyzed: All Exon Locations)
TFRC Transferrin Receptor (Basepairs analyzed: All Exon Locations)
TNF Tumor Necrosis Factor (Basepairs analyzed: All Exon Locations)
UGT1A1 UDP Glucuronosyltransferase Family 1 Member A1 (Basepairs analyzed: All Exon Locations)
UGT1A6 UDP Glucuronosyltransferase Family 1 Member A6 (Basepairs analyzed: All Exon Locations)
UGT1A8 UDP Glucuronosyltransferase Family 1 Member A8 (Basepairs analyzed: All Exon Locations)
UGT1A9 UDP Glucuronosyltransferase Family 1 Member A9 (Basepairs analyzed: All Exon Locations)
VDR Vitamin D Receptor (Basepairs analyzed: All Exon Locations)


The following researched SNPs are analyzed in your GeneSavvy Maximized Wellness Report:

Gene: ABO
SNP – rs8176719

Gene: APOE
SNP – “APOE_GenoType” multiallelic E1, E2, E3, E4
SNP – rs7412
SNP – rs429358
SNP – rs121918393

Gene: C4BPA
SNP – rs45574833

Gene: CETP
SNP – rs5882

Gene: COL1A1
SNP – rs2734272

Gene: COL2A1
SNP – rs2070739

Gene: COMT
SNP – rs4680
SNP – rs4633
SNP – rs6267
SNP rs6269

Gene: CXCR6
SNP – rs2234355

Gene: CYP1A1
SNP – rs1048943

Gene: CYP1A2
SNP – rs2472304

Gene: CYP2A6
SNP – rs5031017
SNP – rs1801272

Gene: CYP2C9
SNP – rs1799853
SNP – rs1057910
SNP – rs2256871

Gene: CYP2D6
SNP – rs28371706
SNP – rs16947

Gene: F3
SNP – rs3917643

Gene: GPX1
SNP – rs1050450

Gene: HFE
SNP – rs1800562
SNP – rs1799945
SNP – rs1800730

Gene: IL17A
SNP – rs2275913

Gene: IL1A
SNP – rs17561

Gene: IL1B
SNP – rs1143634

Gene: IL1RN
SNP – rs878972

Gene: IL6
SNP – rs1524107
SNP – rs1800795

Gene: LPL
SNP – rs328
SNP – rs1801177
SNP – rs328
SNP – rs1801177

SNP – rs1801133
SNP – rs1801131

Gene: MTRR
SNP – rs1801394
SNP – rs1532268

Gene: MTR
SNP – rs1805087

Gene: NAT1
SNP – rs4987076

Gene: NAT2
SNP – rs1208

Gene: NOS1
SNP – rs2682826

Gene: NOS2
SNP – rs1060826

Gene: NOS3
SNP – rs1799983

Gene: PON1
SNP – rs662

Gene: SOD2
SNP – rs4880

Gene: TNF
SNP – rs1800610
SNP – rs3093662

Gene: UGT1A1
SNP – rs35003977
SNP – rs4148323

Gene: UGT1A6
SNP – rs17863783

Gene: VDR
SNP – rs2228570

Maximized Wellness Report



**FOR A LIMITED TIME** Clicking “Add to Cart” will automatically bundle and add our GeneSavvy Variant Exploration Report to your order for FREE

Turn Around Time

Once you purchase this report service, you will receive an email with a link to submit your VCF file. If you do not receive the email within 30 minutes of completing the order or if you need help with your VCF file, please contact us at [email protected]

Once your genetic raw data files are uploaded we will start working on your data conversion! You should receive your GeneSavvy Maximized Wellness Report delivered to your email within 1 business day. Our office is open Monday-Friday, so orders placed on Friday may be delivered on Monday. If you do not receive your report within 1 business day, please contact us at [email protected].

This estimate is assuming the VCF file submitted is in the correct format and without errors. If the VCF file is not in the correct format we will contact you to try to correct the problem. Most problems can be fixed but may add to the turn-around time.

What if you don’t have a VCF file?

VCF files contain the list of genetic variants that differ from a reference human genome. They are more popular than raw genetic sequencing files (.bam, .sam, .fastq) because of their smaller size, which makes them easier to work with. Most genetic sequencing labs will provide you with a VCF data file you can use for GeneSavvy’s secondary analysis services such as our Variant Exploration Service or any of our other Health Report Services. It is also possible for us to take certain BAM files but it requires manual work on our part so incurs extra fees. If you have a BAM file, please contact us.

Common File Types for Genetic Sequencing Data other than VCF:

FASTQ files are usually fresh off the sequencing machine! They contain raw genetic reads that still need to be aligned to a reference genome before they can be processed. These files generally come in pairs of 2 so you’ll see people reference these files as “paired FASTQ files”. When FASTQ files are aligned to a reference genome, it produces a .BAM file.

BAM files are made from the process of aligning a FASTQ file to a reference genome. These files are generally very large (several GB) and contain raw genetic data organized in a way that can really only be understood by specialized software. One more processing step that groups the raw data and removes redundancies produces a much smaller VCF file.

TXT files also usually contain the actual variants found, but they are usually from a genotyping process instead of sequencing. These are usually common files used by ancestry genetic testing companies and are not considered diagnostic grade data. These TXT files also contain variant calls and non-variant calls used for genotyping and common SNP information.

GeneSavvy Reports
Our Variant Exploration spreadsheet files take the data from VCF or TXT files and organizes it in a way that makes it easier to explore and utilize with regards to functional health. Gene names, variant predictions, related health conditions, rarity, and predicted impact are all included in our reports, plus much more. This allows you to explore all the functional aspects of thousands of genetic variants in a much simpler way.

The GeneSavvy Variant Exploration Report is in BETA: Version 0.7, “Ugly Duckling!” Anyone who orders the BETA version now will receive free upgrades through V1! Offer only available for the current BETA Variant Report. Support our BETA and grow your data with us!

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