Chromosome - 4 SNP - rs1801260 Gene Name - CLOCK

Basic Information

Genotype Frequency
  • AA
  • AG
  • GG
Allele Frequency
  • A
  • G

SNP Expression Description

General SNP Description

This SNP has been reported to influence sleep and activity patterns in patients affected by Bipolar Depression. Compared to the T/T homozygotes, carriers of the C allele had a similar degree of severity of Depression, but showed higher activity levels in the evening, a delayed sleep onset and a reduced amount of sleep during the night. In addition to affecting sleep and activity patterns, this SNP has also been linked to Attention Deficit Hyperactivity Disorder (ADHD). C/C carriers presented lower ADHD symptoms while but C/T and T/T carriers showed normal (higher) risk of ADHD symptoms. The C allele of this SNP is also associated with Schizophrenics in the Han Chinese population. Furthermore, Variations of this SNP are also associated with obesity and weight loss. Carriers of the G allele for this SNP displayed greater difficulty in losing weight than non-carriers while on the Mediterranean diet. This gene plays a central role in the regulation of circadian rhythms. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. The function of this gene also plays a role in DNA damage response. Diseases associated with this gene include the following: Delayed Sleep Phase Syndrome, Bipolar Disorder, Narcolepsy, Major Depression, Mood Disorders, Colon Carcinoma, Schizophrenia, Shock, Tumors and Obesity.