Chromosome - 2 SNP - rs4245791 Gene Name - ABCG8

Basic Information

Genotype Frequency
  • TT
  • CT
  • CC
Allele Frequency
  • T
  • C

SNP Expression Description

How does this fit in to your daily life?

Individuals with this SNP are encouraged to consider a low fat diet, increase foods rich in plant sterols (whole grains, legumes, nuts, seeds), stress management and maintaining consistent physical exercise. Individuals with this SNP are encouraged to avoid processed foods, high fat diets (pro-inflammatory foods, margarine), nicotine cessation and sedentary lifestyle.

Further research is being conducted on this SNP, please consult with your physician before taking any action. Even though current research indicates the possibility that current diseases are associated with this SNP, individuals with this SNP should be aware that this does not necessarily indicate that such diseases are present nor likely.

For more information, please schedule a consult with one of our HealthCoach7 Genetic Specialist.

General SNP Description

This SNP is associated with reduced phytosterol levels and thus reduced risk for Coronary Artery Disease (CAD). This SNP is associated with high intestinal cholesterol absorption, which increases the risk for cardiovascular disease. In addition to that, this SNP has been linked to have an effect on total cholesterol levels. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia. The protein made by this gene serves as a transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
For more information, please schedule a consult with one of our HealthCoach7 Genetic Specialist.