Chromosome - 13 SNP - rs6311 Gene Name - HTR2A

Basic Information

  • SNP rs6311
  • Chromosome 13
  • Gene Name HTR2A
  • Weight of evidence 158
Genotype Frequency
  • CT
  • CC
  • TT
Allele Frequency
  • C
  • T

SNP Expression Description

How does this fit in to your daily life?

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General SNP Description

This SNP is located in the promoter region (a region of a gene that initiates the copy of that gene) of  HTR2A gene (or serotonin receptor gene). In addition to that, some research shows that the T allele of this SNP is protective against suicide. However, the complement C allele of this SNP has been associated with non-violent and impulsive suicidal behavior. In addition to that, the (C;C) genotype was associated with more anger and aggression-related behavior. The G allele of this SNP is associated with Provoked Vestibulodynia, which is the most common type of superficial pain in the vestibule (where the vulva or the skin on the outside meets the vagina) region of the vagina along with other comorbid or related symptoms of pain. Women with this disorder are hypersensitive to light touch to the vestibule, such as during sexual intercourse or insertion of tampons. The degree of pain is variable for each person. Treatment options include: psychological therapies used in chronic pain management, topical lidocaine or cromoglycate before penetration, pelvic physical therapy, tricyclic antidepressants or anticonvulsants can be used to treat chronic pain as well. Some research shows that chronic pain can be treated with fish oil (DHA+EPA). In addition to that, a number of studies have linked low Vitamin D with chronic pain thus in certain cases Vitamin D supplementation might help with chronic pain. The HTR2A gene is associated with a risk for rheumatoid arthritis. In addition to that, the cumulative effects of  this SNP as well as rs7305115 in TPH2 gene and rs6295 in HTR1A in combination with childhood adversity contribute to individual differences in reward sensitivity or how likely an individual will learn/perform a certain task with a conditioned or unconditioned reward. In another study, researchers were able to associate plasticity and region specificity of HTR2A gene expression regulation in human brain with age, which is important for the interaction with other neurotransmitter systems and for the occurrence of times during overall development that have increased vulnerability to neuropsychiatric or neurodegenerative disorders. Neuroplasticity is a general term that encompasses both synaptic and non-synaptic plasticity and it refers to changes in neural pathways and synapses due to changes in behavior, environment, neural processes, thinking, emotions, as well as changes resulting from bodily injury. Essentially this refers to how the brain changes throughout life.


For more information, please schedule a consult with one of our HealthCoach7 Genetic Specialist.