Chromosome - 11 SNP - rs662799 Gene Name - APOA5

Basic Information

  • SNP rs662799
  • Chromosome 11
  • Gene Name APOA5
  • Weight of evidence 254
Genotype Frequency
  • AA
  • AG
Allele Frequency
  • A
  • G

SNP Expression Description

General SNP Description

This SNP is associated with elevated plasma triglyceride levels (i.e. blood lipid), this is one of the major risk factors for heart attack. In addition to that, in a research study done on Chinese children and adolescents associated the G allele of this SNP with a greater likelihood for an individual to become obese. The same study but done on children and adolescents that were already obese associated G allele with higher non-HDL-C levels, which is one of the major risk factors for cardiovascular disease. Since this SNP is associated with elevated triglyceride levels, the G allele was also associated with metabolic syndrome, which is essentially a group of risk factors that raise the likelihood for heart disease and other health problems such as diabetes and stroke. The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. Mutations in this gene have been associated with the following disease: hypertriglyceridemia, hypertriglyceridemias familial, hyperlipidemia familial combined, endogenous hypertriglyceridemia, dyslipidemia, hyperlipoproteinemia type iii, cardiovascular diseases, coronary artery disease, coronary heart disease and atherosclerosis. Significant SNPs of this gene include: rs2075291: Associated with high triglyceride levels in Asians, rs3135506: Associated with hypertriglyceridemia and rs662799: Prevents weight gain from high fat diets.

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